SCFA may have a favorable impact on metabolism through activation of G protein-coupled receptors in endocrine and colon epithelial cells that, in turn, release anorectic hormones, such as glucagon-like peptide 1 (GLP) and peptide YY (PYY), which may contribute to reducing food intake and protecting individuals against obesity and diabetes, as shown in our results. This evidence concerns the gene GCG and obesity due to melanocortin 4 receptor deficiency.