Although this molecule has been reported to play a role in post-translational protein changes and pathways that regulate several metabolic processes [33], data from the literature on its actual effect on metabolic health are not univocal: some studies reported potential beneficial effects from increasing HDL-C, such as reducing triglycerides levels, improving long-chain omega-3 levels in plasma phospholipids [34] and obesity-associated insulin resistance [35] and increasing LDL-C and apoB levels [36]. Here, APOB is linked to obesity due to melanocortin 4 receptor deficiency.