On the other hand, in AD Aβ can induce an increase in STEP via impairing the ubiquitin-proteosome system as well as via activating the α7 nicotinic acetylcholine receptors (α7nAChRs) [40,41,42] which leads to intracellular calcium influx, activating calcineurin (protein phosphatase 2B (PP2B)). The gene discussed is CHRNA7; the disease is Alzheimer disease.