Moreover, in our previous study [21], we found that MO can alleviate homocysteine-induced AD-like pathological changes including Aβ production, Tau hyperphosphorylation, and neurodegeneration via decreasing BACE1, GSK-3β, CDK5, CaMKII, increasing PP2A activities, and improving oxidative stress and cognitive deficits. Here, MAPT is linked to Alzheimer disease.