This transcriptome analysis, showed for the first time a wide spectrum of favorable effects of MO supplementation in this mouse model of NASH development that correlates with histological findings; since HF animals showed a significantly increased of inflammatory nodules and early fibrosis in liver tissue; while Moringa treated animals reduced inflammatory infiltrate, collagen staining and αSMA-positive cells. The gene discussed is ACTA1; the disease is metabolic dysfunction-associated steatohepatitis.