As shown in Figure 6, the insulin-resistant cells treated with WPS and P-1 significantly increased the protein-expression levels of Akt and PI3K compared with the model IR group (p < 0.05), which confirmed that P. eryngii polysaccharides WPS and P-1 can effectively activate the PI3K-Akt signaling pathway to alleviate insulin resistance. The gene discussed is INS; the disease is Insulin resistance.