RHO and cancer: It is well known that the mevalonate pathway provides intermediates such as geranylgeranyl-pyrophosphate and farnesyl-pyrophosphate for the posttranslational prenylation and cell membrane anchoring of several proteins, including the RAS, RAC, Rho, and GTPase families involved in cell growth and cell proliferation in cancer [52,53]; for example, active Rho proteins are involved in numerous cellular events in cancer progression, including cell cycle progression, migration, and transformation [50].