CASP8 and cancer: In addition, researchers have found that Gg exhibits important chemopreventive and suppressive ac-tivities on cancer cell lines by arresting the cell cycle in the G1 phase and inducing the down-expression of cyclin D1 and induced apoptosis by activating caspases 8, 9, and 3 in cell lines DU145 and DLD1 [45,46,47,48].