Treatment options for RA include nonsteroidal anti-inflammatory drugs (NSAIDs), selective cyclooxygenase-2 (COX-2) inhibitors, corticosteroids, biologic disease-modifying antirheumatic drugs (bDMARDs), classic csDMARDs (methotrexate, hydroxychloroquine, etc.), and targeted synthetic DMARDs. This evidence concerns the gene PTGS2 and rheumatoid arthritis.