SCARB1 and neoplasm: This idea is based on two important premises: (a) most anticancer drugs are poorly soluble in water, so they can be easily incorporated into the rHDL core [3,6,10,18], and (b) once rHDL binds to the SR-B1 present on the surface of the tumor cell, it contributes to the release of hydrophobic substances directly into the cytosol, thus increasing significantly the therapeutic efficacy [9,10,19].