In a previous study, we have analyzed effects of H2O2 on melanogenesis using human melanoma SK-Mel-2 cells and mouse melanoma B16F10 cells by measuring melanin content and analyzing expression levels of melanogenesis-related proteins [26], including cAMP-responsive element binding protein (CREB), microphthalmia-associated transcription factor (MITF), tyrosinase, and phenylalanine hydroxylase (PAH). Here, PAH is linked to melanoma.