Immunoblot assays for the apoptosis-related proteins, Bcl-2, Bcl-XL, cleaved caspase-3, cleaved caspase-9, and cleaved PARP, were performed to assess whether the apoptotic cell death mechanism is increased in CRC cells co-treated with JNC-1043 and IR. This evidence concerns the gene BCL2L1 and colorectal carcinoma.