In the present study, we synthesized a novel PPT derivative from APP, (5S)-5-(4-benzyloxy-3,5-dimethoxy-phenyl)-5,9-dihydro-8H-furo [3’,4’:6,7] naphtho [2,3-d][1,3]dioxol-6-one (JNC-1043), and explored its anticancer drug and radiosensitizer effects and the underlying molecular mechanisms in CRC cells [17]. The gene discussed is APP; the disease is colorectal carcinoma.