The reported targets (I–V, Figure 1) with these scaffolds revealed potent cytotoxic activities against various human cancer cell lines with different mechanisms, such as the inhibition of the dihydrofolate reductase enzyme and NUDT5 (Nudix Hydrolase 5) to silence hormone signaling in breast cancer [16,17,18,19]. Here, NUDT5 is linked to breast carcinoma.