A total of 172 KEGG pathways were enriched, of which 43 were significantly different, and the 10 with the greatest differences are listed in Figure 4A. These pathways included the AGE-RAGE signaling pathway (hsa04933), thyroid hormone signaling pathway (hsa04919), inflammatory mediator regulation of TRP channels (hsa04750), alcoholism (hsa05034), phosphatidylinositol signaling system (hsa04070), proteoglycans in cancer (hsa05205), amoebiasis (hsa05146), human T-cell leukemia virus 1 infection (hsa05166), toxoplasmosis (hsa05145), and osteoclast differentiation (hsa04380). The gene discussed is RENBP; the disease is alcohol dependence.