Ginsenoside Re helps in the dopaminergic neuron protection from MPTP-induced apoptosis via the expression of Bcl mRNA, elevating Bcl-2 protein (an apoptotic protein) levels, lowering the Bax protein (a pro-apoptotic protein) levels, the expression of Bax mRNA and inhibiting the activation of caspase-3 in the PD mouse model [101]. This evidence concerns the gene BAX and Parkinson disease.