For this clinical isolate, treatment with most CFS did not abolish this morphologic form, except for CFS mainly from L. crispatus strains, i.e., CFS from L. crispatus BC1, BC5, BC6, and bf-CFS from L. crispatus BC3, BC4, and BC8. The gene discussed is CFB; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.