PSMD1 and COVID-19: Moreover, immune activation in hypertensive patients was largely augmented under COVID-19, providing a novel potential explanation for the adverse course of the disease related to a hyperinflammatory response in these patients with cardiovascular disease [18,19], Single-cell RNA sequencing hence might be a favorable tool to characterize the underlying molecular pathways in patients with developing adequate levels of IgG antibodies against the S1 protein but inadequate levels of neutralizing SARS-CoV-2 virus antibodies.