GCG and vascular dementia: Furthermore, it was reported that GLP-2 potentiated L-type Ca2+ channel activity in primary hippocampal neurons via the activation of cAMP-dependent protein kinase A (PKA) [72] while GLP-2’s role in improving learning and memory in a mouse model of vascular dementia and a juvenile-onset diabetes in rats was mediated through ERK pathway in hippocampal neurons [73].