In the initial phase of granuloma formation, CD4+ T lymphocytes and other inflammatory cells release chemokines such as CCL2, CCL3, CCL4, CCL5, CCL7, CCL11, CCL12, CCL17, CCL22, and CCL24, which bind to their cognate receptors at the eosinophil surface and regulate eosinophil migration [27,59,60,61,62,63,64]. Here, CD4 is linked to Granuloma.