The effects of disease remission and intestinal anti-inflammatory agents were positively correlated with UC, while surgical resection, drugs for peptic ulcers and gastro-oesophageal reflux disease (GORD) and antacids as well as EPP and insulins and analogues were positively associated with the effect of CD on the gut microbiome (Figure 6c). The gene discussed is INS; the disease is gastroesophageal reflux disease.