Down-regulation of extracellular cytokine activity (processes Th1 and Th2 cell differentiation, inflammatory bowel disease, cytokine-mediated signaling pathway, and immune response) was accompanied by expression of interleukin-12 subunit beta (il12ba), chemokine (C-C motif) ligand 25b (ccl25b), chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1; cxcl12), and monocyte chemotactic protein 1B (mcp-1) (Supplementary Table S4). Here, CCL2 is linked to inflammatory bowel disease.