CD4 and Alzheimer disease: To determine the effect of a mixture of heat-killed MP01 and MP02 on systemic T cell responses, the weight of spleen and the population of IL4+CD4+ T cells, IFN-γ+CD4+ T cells in the spleen, and CD4+CD25+Foxp3+ T cells in the Peyer’s patch of HDM-extraction induced AD mice using flow cytometry are shown in Figure 3.