However, our results demonstrated that the mixture of heat-killed MP01 and MP02 strains reduced IL4+CD4+ T cells (Th1) and IFNγ+CD4+ T cells (Th2) cells in the spleen, whereas CD4+CD25+Foxp3+ cells (Treg) in the Peyer’s patch were not changed in HDM-extraction-induced AD mice. The gene discussed is CD4; the disease is Alzheimer disease.