The deoxygenation-activated drug tirapazamine (TPZ) was loaded onto Ti3C2 nanosheets, glucose oxidase (GOX), and chloroperoxidase (CPO) to furnish Ti3C2-GOX-CPO/TPZ (TGCT) which was implanted into nanosized cancer cell-derived membrane vesicles with high-expressed CD47 (meTGCT). The gene discussed is HAO1; the disease is cancer.