PNPs = polymeric nanoparticles; FDA = U.S. Food and Drug Administration; PLGA = poly (d, l-lactide-co-glycolide); PSMA = prostate specific membrane antigen; NSCLC = non-small-cell lung cancer; mCRPC = metastatic castration-resistant prostate cancer; PEG = poly (ethylene glycol); PLA = poly (Lactic acid); PEBCA = polyethylbutylcyanoacrylate; PBCA = polybutylcyanoacrylate; mPEG = methoxypolyethylene glycol; siRNA = small interfering RNA; eIF5A = Eukaryotic translation initiation factor 5A; PEI = polyethylenimine. This evidence concerns the gene EIF5A and non-small cell lung carcinoma.