Against the background of further AP treatment for 5.1 years, the previously manifested positive effect on the profile of inflammatory markers abated, and an increase in serum levels of IL-2, IL-6, IL-1A, IFN-γ, IL-4, and IL-10 appeared, emphasizing the profound return of inflammatory imbalance as the disease became chronic. This evidence concerns the gene IL6 and alkaline phosphatase measurement.