IL6 and alkaline phosphatase measurement: In line with previously published meta-analyses [2,4,6], research performed by our group [7,8] established the significantly higher levels of anti-, and pro-inflammatory cytokines (interleukin (IL)-4, IL-6) in drug-naïve FEP patients compared to control subjects (CSs), and AP treatment was related to decreased concentrations of cytokines (IL-2, IL-4, IL-6, IL-8, interferon (IFN)-γ).