Uptegrove et al. [6], in a meta-analysis, included 570 AP-naïve FEP patients compared to 683 CSs and identified that IL-1B, IL-6, and TNF-α were significantly elevated among the patient group and there was no significant difference in IL-2, IL-4, and IFN-γ between groups. This evidence concerns the gene TNF and alkaline phosphatase measurement.