However, a study with multiple low-dose STZ injections (60 mg/kg, 4 times) after being fed with a high-fat diet (six weeks) showed different results, finding that PPAR-γ protein levels were significantly reduced in the livers of T2DM mice, while Angelica sinensis polysaccharide treatment significantly increased PPAR-γ expression [29]. This evidence concerns the gene PPARG and type 2 diabetes mellitus.