PPARA and diabetes mellitus: In a diabetes model induced by a high-fat diet (four weeks) combined with STZ injection (40 mg/kg, single dose), it was found that the expression of PPAR-α was lower and the expression of PPAR-γ was higher in diabetic rats, but the intervention with Epigynum auritum extract not only increased the expression of PPAR-α but also inhibited the expression of PPAR-γ in the liver of diabetic rats [27].