Similarly, in the diabetes model induced by a high-fat diet (four weeks) combined with STZ injection (40 mg/kg, 2 times), it was found that the expression of PPAR-α was lower and the expression of PPAR-γ was higher in diabetic mice, but the intervention with a flavonoid-rich extract from Sophora alopecuroides L. not only increased the expression of PPAR-α but also inhibited the expression of PPAR-γ in the livers of diabetic mice [28]. This evidence concerns the gene PPARG and diabetes mellitus.