MTOR and Hyperglycemia: Recent studies have shown that the STZ-induced hyperglycemia pattern multiplies thioacetamide-induced acute liver injury, possibly through inhibition of the AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR)-mediated induction of autophagy, resulting in NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome activation in Kupffer cells [9].