The construction of T2DM animal models is mainly based on transgenic animals and chemical reagent induction [5], in which streptozotocin (STZ) is often used in animal experiments to simulate diabetes models—depending on the structural similarity of STZ to 2-deoxy-D-glucose—and can selectively destroy pancreatic β-cells via glucose transporter (GLUT)-2 [6,7]. Here, SLC2A2 is linked to diabetes mellitus.