It also improved metabolic functions, including increasing HDL-C (5.1%, 95% CI 3.6–6.7%), while decreasing LDL-C (−11.0%, 95% CI, −12.3 to −9.6%), LDL-C/HDL-C ratio (−15.7%, 95% CI −18.0 to −13.5%), Lp(a) (−25%, 95% CI −32.9 to −17.1%), fibrinogen (−5.5%, 95% CI −7.8% to −3.2%), and PAI-1 (−25.1%, 95% CI −33.6% to −15.5%) in postmenopausal women with and without diabetes [87]. The gene discussed is SERPINE1; the disease is diabetes mellitus.