Numerous population-based experiments showed that the levels of betatrophin in the T2D population are about 3 times higher than in the non-diabetic population [11] and that the risk of T2D in a population with a high level of betatrophin was increased by almost 6 times when age, gender, race, blood lipids, and other factors were controlled, indicating that the level of betatrophin can be used as an independent predictor of T2D. The gene discussed is ANGPTL8; the disease is type 2 diabetes mellitus.