Interestingly, among the proteins significantly enriched in MAP-resistant individuals, pathways such as “Epstein–Barr virus infection”, “Ammonium metabolic processes”, “Diabetes mellitus type I”, and “Inflammatory bowel disease” were enriched due to the higher abundance of “Toll-like receptor 2” and “Major histocompatibility complex, class II, DR alpha” proteins (Figure 1A). The gene discussed is HLA-DRA; the disease is inflammatory bowel disease.