INS and obesity due to melanocortin 4 receptor deficiency: Furthermore, indicative of different ‘at risk’ subtypes, our group, using metabolic profiling, proposed different pathophysiological processes in 71 GDM women with obesity when stratified by different treatment modalities used to achieve glycaemic control; GDM women who were ultimately treated with insulin displayed a more insulin resistant profile compared to those who were managed with diet suggesting insulin insufficiency in this latter group [56].