SLC40A1 and hemochromatosis type 1: Altès et al. [9] studied hemochromatosis patients with the classical HFE homozygous mutation and the c.44–24G>C SLC40A1 polymorphism (rs1439816) and associated this FPN gene polymorphism with the amount of iron overload, the presence of liver disease, and, consequently, clinical aggressiveness.