CLOCK and metabolic disease: On the other hand, although TRF corrected the attenuation of peripheral biological clock oscillations caused by LL [34] and alleviated the development of metabolic disease in a biological clock defect/metabolic disorder model in mammals [30,31], the relationship between the central and peripheral biological clocks in fish is more complex, and there does not seem to be a strict hierarchy between the central and peripheral biological clocks [83], which may be one of the reasons why TRF failed to alter the lipid deposition in the present study.