Although, under the molecular profile, the renin-angiotensin-aldosterone system (RAAS) is decisively involved in the pathogenesis of COVID-19 taking the stage, since the development of the acute phase of the viral infection, RAAS seems to also play a crucial role in the pathogenesis of long-term COVID, due to its action on different organs and tissues [32,33]. The gene discussed is REN; the disease is viral infectious disease.