The proposed pathomechanism of headache in COVID-19 patients is probably the result of direct neuronal damage of the trigeminal nerve by SARS-CoV-2, or the indirect effects of hypoxia, coagulopathy, and cytokine storm (such IL-1β, IL-6, and TNF-α) that are involved in various pathological pain mechanisms [40,41]. Here, IL1B is linked to COVID-19.