The possible role of ROS in dendritic and synaptic apoptosis [20] and the association of schizophrenia with oxidative stress through reduced levels of brain-derived neurotrophic factor (BDNF) [45,46] potentially includes oxidative stress in the course of neurostructural changes, clearly positioning it within the framework of neuroprogressive theories and not ruling out its role in pathological neurotransmission [13]. This evidence concerns the gene BDNF and schizophrenia.