CXCR1 and neoplasm: CXCL8 binds to CXCr1/2 to induce inflammatory responses and new blood vessel formation, and it modulates immune responses [27]; also, CXCL8 can induce tumorigenesis by participating in the mechanism of apoptosis resistance, thereby inducing tumorigenesis [28], and it can regulate tumor angiogenesis by pro mot ing the production of matrix metalloproteinases as well as the survival and proliferation of endothelial cells [29,30].