CXCL8 and esophageal squamous cell carcinoma: For the validation cohort, the AUC of anti-CXCL8 autoantibody was 0.752 (95%CI: 0.696–0.808) and anti-CXCL8 autoantibody could distinguish 47.1% of ESCC patients at the specificity of 77.9% (Figure 4D).