There were good correlations (r > 0.4) between LMR, NLR, WMR, CHR, NT-proBNP and NYHA functional classification, and LMR, NLR, NT-proBNP, LMR combined with WMR, and LMR combined with NT-proBNP had good diagnostic values (AUC > 0.7) for HF in patients with HFpEF. The gene discussed is NPPB; the disease is hydrops fetalis.