Statistical results showed that NLR (odds ratio (OR) = 1.388, 95% CI 1.031–1.870, p = 0.031), LMR (OR = 0.463, 95% CI 0.348–0.617, p = 0.000) and NT-proBNP (OR = 1.002, 95% CI 1.000–1.003, p = 0.008) levels were independent predictors for HF after adjusting corresponding confounding factors (Table 3). The gene discussed is NPPB; the disease is hydrops fetalis.