The factors in the baseline characteristics with statistical difference (p < 0.5) between NYHA I and NYHA II–IV groups were included in univariate logistic regression analysis, and the results showed that age, hypertension, diabetes, scr, NLR, PLR, LMR, MHR and NT-proBNP are independent predictors for HFpEF. This evidence concerns the gene NPPB and hypertensive disorder.