CD274 and breast cancer: In more detail, as mentioned above, Lee et al. stated that rs822336C and rs822337A haplotypes are related with reduced PD-L1 expression [30], whereas at the same time it has been found that breast cancer patients with decreased PD-L1 expression are characterized by worse survival rates [36] as well as that in TNBC the PD-L1 downregulation is associated with unfavorable prognosis [37].