ALK and central nervous system cancer: They used a variety of sequencing platforms including WGS, WES, and RNA-seq, thereby highlighting that high-grade childhood gliomas in the brain hemispheres comprise new subgroups, with a prevalence of ALK gene fusions NTRK1/2/3, ROS1 (ROS Proto-Oncogene 1, Receptor Tyrosine Kinase) or MET (MET proto-oncogene, receptor tyrosine kinase) [70].