Iacobucci et al. [140] compared the genomic characteristics of 159 pediatric and adult acute erythroleukemia (AEL) cases with non-AEL myeloid disorders and defined five age-related subgroups with distinct transcriptional profiles: adult, TP53 mutated; NPM1 mutated; KMT2A mutated/rearranged; adult, DDX41 mutated; pediatric, NUP98 rearranged. Here, DDX41 is linked to acute erythroid leukemia.