THADA and type 2 diabetes mellitus: Next, differentially methylated genes (134 genes) were observed after six months of exercise intervention, including Myocyte Enhancer Factor 2A (MEF2A) (exercise transcription factor), Thyroid adenoma-associated protein (THADA) (T2DM candidate gene), NADH:ubiquinone oxidoreductase subunit C2 (NDUFC2) (mitochondrial function), and Interleukin-7 (IL7) (cytokine).