Model 1 adjusted for possible confounding factors of age, sex, height, serum creatinine, ALT, hs-CRP, and total vitamin D. Individuals with class I and class II sarcopenia exhibited a significantly increased risk of metabolic syndrome (adjusted ORs [95% CI] compared with normal reference; class I, 2.42 [2.33–2.52]; class II, 2.62 [2.45–2.80]). The gene discussed is CRP; the disease is sarcopenia.