A study conducted by Isoardo et al. (2012) [20] revealed that levels of aquaporin-4 (AQP-4) channel in GBM cells are higher in patients with seizures than in seizure-free individuals, and this seems to be related to post-transcriptional modifications, since, despite similar mRNA levels in the two populations, protein levels are much higher in patients with tumor-related epilepsy [20]. The gene discussed is AQP4; the disease is glioblastoma.