HIF-1α induction in hypoxic conditions provokes a mesenchymal shift in GBM cells, through the activation of other key regulators of transcription, including nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB), CCAAT/enhancer-binding protein β (CEBP-β), and Janus kinase 2 (JAK2) and STAT5B pathway [23]. This evidence concerns the gene JAK2 and glioblastoma.