From a structural point of view, it results in neuronal and glial loss, altered blood-brain barrier permeability, and recruitment of astrocytes, microglial cells, and circulating macrophages, as well as increased concentrations of cytokines, such as interleukins (ILs) IL-1β, IL-6, IL-8, tumor necrosis factor (TNF)-α, chemokines, and extracellular matrix remodeling enzymes, including matrix metalloproteinase (MMP)-2 and MMP-9, that promote both tumor proliferation and invasiveness as well as increase seizure susceptibility [10,11]. This evidence concerns the gene TNF and neoplasm.