The most common toxicities associated with HAIC included AST and ALT elevation (both 34.3%), thrombocytopenia (17.1%), bilirubin elevation (8.6%), general weakness (8.6%), dyspepsia/anorexia (2.9%), nausea/vomiting (2.9%), gastrointestinal (GI) bleeding (2.9%), hyponatremia (2.9%), ascites aggravation (2.9%), and hepatic encephalopathy (2.9%). This evidence concerns the gene GPT and Ascites.