Observing the extracellular matrix (ECM)–receptor interaction compounds, IgG4-ROD samples had transcripts responsible for ECM adhesion altogether with their integrin domains downregulated compared to MALT lymphoma samples; namely, collagen, laminin, thrombospondin (THBS), α1, α 5, α 6, α 7 and β4 (ITGB4). This evidence concerns the gene ITGB4 and MALT lymphoma.