This pathway is affected by COVID-19 through the following sequence: When SARS-CoV-2 binds to ACE2, there is an accumulation of AngII, a decrease of Ang1-7 and an unperturbed RAAS activation via the AngII/angiotensin type 1 receptor (AT1R) (Figure 3). The gene discussed is ACE2; the disease is COVID-19.