FFAR4 and viral infectious disease: In addition, high consumption of omega-3 PUFAs results in the reduction of proinflammatory cytokines such as IL-1β, IL-6, IL-8, and TNF-β; inhibits adhesion molecules expression (VCAM, ICAM, and selectins) [171] and other important anti-inflammatory mechanisms including regulating cell membrane phospholipids composition [172], modulation of lipid rafts implicated in viral infections [173] decreasing expression of proinflammatory genes by inactivation of NF-κB [174] and acting like a metabolic regulator of inflammatory responses through G-protein-coupled receptor 120 (GPR120) [175].