In COVID-19 patients, autopsies revealed intussusceptive angiogenesis and increased expression of pro-angiogenic factors, such asplatelet-derived growth factor (PDGF), VEGF, VEGFR1, matrix metalloproteinase 2 (MMP-2), TIMP1, HIF-1α, intracellular adhesion molecule1(ICAM-1), super family 1A (TNFRSF1A), IL-6 and ACE2, compared withinfluenza and control patients [53]. The gene discussed is ACE2; the disease is COVID-19.