MYH7 and Mitral regurgitation: A higher degree of mitral valve regurgitation is found in patients with a mutation in the MYH7 gene [28], and MYH7 is proposed as one of the genes that are most commonly mutated in early-onset AF [29]; HCM patients with likely pathogenic or pathogenic mutations in MYH7 had a higher rate of incident AF compared with other sarcomeric genes [30].