Moreover, hypoxia regulates some immune suppressive signals, such as PD-L1, indoleamine 2,3-dioxygenase (IDO), interleukin-6 (IL-6), IL-10, and induces the upregulation of chemokines such as chemokine (C-C motif)-ligand (CCL)-22 and CCL28, that recruit Tregs at tumor sites, altering the equilibrium between T-effectors and Tregs. This evidence concerns the gene IDO2 and neoplasm.