In addition, ND strongly decreased hepatic mRNA expression of Scd1 and FASN activity in the ND + normoxia group compared with those of the HFD + normoxia group, and ND also strongly decreased hepatic mRNA expression of Acc1 and Scd1, and FASN activity in the ND + HE group compared with those of the HFD + HE group (Figure 5F,H,I). The gene discussed is SCD; the disease is hereditary elliptocytosis.