SCD and hereditary elliptocytosis: Furthermore, the hypoxia exposure decreased the mRNA expression of Fasn, Scd1, and Srebp-1c significantly in the HFD + HE group compared with those in the HFD + normoxia group; while after replacing a HFD with ND feeding, the ND + normoxia group achieved more significant changes in the measured variables than those of the ND + HE group.