Additionally, the protein expression of HIF-1α and DEC1 were higher, and the mRNA expression of Srebp-1c was lower in the liver of the ND + HE group than those of the ND + normoxia group (Figure 7A–C); the protein expression of HIF-1α and DEC1 in the liver of the ND + HE group were higher than those of the HFD + HE group (Figure 7A,B). This evidence concerns the gene HIF1A and hereditary elliptocytosis.