Combined blocking of C5a and PD-L1 can affect the number of MDSCs in the TME and reduce their immunosuppressive function, thus reversing the depletion state of CD8+T cells, increasing the number of tumor-infiltrated CD8+T cells, and promoting the production of endogenous IL-10 to enhance the anti-tumor function [109]. The gene discussed is CD8A; the disease is neoplasm.