ALB and Abnormal blood ion concentration: It is defined as a glomerural filtration rate (GFR) less than 60 mL/min/1.73 m2 in combination by one or more markers of kidney dysfunction [5] including albuminuria (albumin excretion rate >30 mg/24 h, albumin to creatinine ratio >30 mg/g), abnormalities in urine sediment, electrolytic disorders due to tubular dysfunction, histological and structural abnormalities and/or history of kidney transplantation [6].