TRAP1 and prostate adenocarcinoma: In an in vivo experiment, TRAP1 transgenic mice showed an accelerated incidence of invasive prostate adenocarcinoma characterized by increased cell proliferation and reduced cell apoptosis, and conversely, homozygous deletion of TRAP1 delayed prostate tumorigenesis in mice without affecting hyperplasia or prostate intraepithelial neoplasia [65].