HOXB13 and Familial prostate cancer: In an in vitro experiment, HOXB13 and MEIS1 interact to regulate the proliferation and apoptosis of multiple prostate cancer cell lines (DU145, E006AAT, PC3, CWR22RV1, LNCaP, LNCaP C4-2, and VCap) [28], which is believed to regulate the development of prostate cancer.